反应详情

N-(6-(4-Aminophenoxy)pyrimidin-4-yl)phenylamine (55.6 mg, 0.200 mmol) and (3-methylsulfonylphenyl)carbamic acid phenyl ester (63.8 mg, 0.220 mmol) were heated and stirred in dimethylsulfoxide (1 ml) at 85° C. for 2 hours. The reaction solution was distributed between ethyl acetate and water, the organic layer was washed with 1N aqueous sodium hydroxide, water and saturated brine and dried over anhydrous magnesium sulfate, the drying agent was filtered off and the filtrate was distilled off under reduced pressure. The obtained crude product was suspended in ethyl acetate, the suspension was diluted with hexane, and the crystals were filtered out, washed with hexane and then blow-dried to obtain the title compound (77.0 mg, 0.162 mmol, 81%) as colorless crystals.

1. washthe organic layer was washed with 1N aqueous sodium hydroxide, water and saturated brine
2. dry with materialdried over anhydrous magnesium sulfate
3. filtrationthe drying agent was filtered off
4. distillationthe filtrate was distilled off under reduced pressure
5. customThe obtained crude product
6. filtrationthe crystals were filtered out
7. washwashed with hexane
8. customblow-dried