HCID 24903490, compound → HCID 68618190, compound

Participants

Reaction Steps

To a solution of (2R)-tert-butoxycarbonylamino-(4-nitro-phenyl)-acetic acid (350 mg, <1.18 mmol) in absolute ethanol (15 mL) was added a small amount of 10% palladium on carbon and the mixture stirred under an atmosphere of hydrogen for 16 hours. The reaction mixture was filtered through a pad of Celite and the Celite eluted with absolute ethanol. The filtrate was concentrated in vacuo then purified by chromatography over silica gel gradient eluted between 0 and 7% v/v methanol in dichloromethane. (2R)-(4-Amino-phenyl)-tert-butoxycarbonylamino-acetic acid was obtained as a yellow oil (146 mg, 46%).

Provenance & Evidence