Bromotrimethylsilane → HCID 57935153, compound

Participants

Reaction Steps

To a solution of (4-{(R)-1-[(1S,2S)-1-(2-fluoro-4-iodo-phenylcarbamoyl)-2-phenyl-propyl]-2,5-dioxo-imidazolidin-4-yl}-phenoxymethyl)-phosphonic acid dimethyl ester (prepared as described in example 63) (79 mg, 0.11 mmol) in dichloromethane (2.0 mL) was added bromotrimethylsilane (0.12 mL, 0.88 mmol) at room temperature. After 4 hours, the reaction was concentrated in vacuo and diluted with water (5 mL). The precipitated solids were filtered and dried to give (4-{(R)-1-[(1S,2S)-1-(2-fluoro-4-iodo-phenylcarbamoyl)-2-phenyl-propyl]-2,5-dioxo-imidazolidin-4-yl}-phenoxymethyl)-phosphonic acid (51 mg, 68%).

Provenance & Evidence