HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1,2-Epoxypropane → (R)-tert-Butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1,2-Epoxypropane | HCID 146261 | — |
| Reactant | (2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid | HCID 16213170 | — |
| Reactant | (R)-tert-butoxycarbonylamino-{4-[2-(tetrahydropyran-2-yloxy)-ethoxy]-phenyl}-acetic acid | HCID 68617730 | — |
| Product | (R)-tert-Butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid | HCID 68620103 | — |
Reaction Steps
Prepared by the same method as described in example 3 except that (i) 2-chloro-4-iodo-aniline was used in place of 4-bromo-2-chloro-aniline in step 1, and (ii) (R)-tert-butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 2. (R)-tert-Butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid was prepared as described in example 48 except that (R)-2-methyl-oxirane was used in place of 2-(2bromo-ethoxy)-tetrahydropyran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612212B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-9f20a8e1752c467da7840a1225c65731 |
| Source note | uspto-grants-2009_11 |