HCID 86614675, compound → HCID 86614674, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of [(1S,2S)-1-(4-ethynyl-phenylcarbamoyl)-2-phenyl-propyl]-carbamic acid tert-butyl ester (300 mg, 0.79 mmol) in formic acid (5 mL) was heated to 50° C. for 1 hour. The reaction was concentrated in vacuo, basified with saturated aqueous sodium hydrogen carbonate and extracted with ethyl acetate (2×20 mL). The combined organic extracts were washed with water, brine, dried over sodium sulfate, filtered and concentrated in vacuo to give (2S,3S)-2-amino-N-(4-ethynyl-phenyl)-3-phenyl-butyramide as a foam (214 mg, 92%).

Provenance & Evidence