4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

HRID 1433815Notes

Reaction equation

HRID 1433815 reaction equation
NC(C)(C)C[O:4]C1C=CC(C#N)=CC=1F.[C:16]([C:18]1[CH:36]=[CH:35][C:21]([O:22][CH2:23][C:24]([NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:26])[CH3:25])=[C:20]([F:37])[CH:19]=1)#N>>[F:37][C:20]1[CH:19]=[C:18]([CH:16]=[O:4])[CH:36]=[CH:35][C:21]=1[O:22][CH2:23][C:24]([NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 86605237Tert-butyl [2-(4-cyano-2-fluorophenoxy)-1,1-dimethylethyl]carbamate

Product 1

HCID 57934591Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

Procedure

Synthesized from 4-(2-amino-2-methylpropoxy)-3-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 19, tert-butyl [2-(4-cyano-2-fluorophenoxy)-1,1-dimethylethyl]carbamate (1.0 g) was used according to an analogous synthetic method to Preparation Example 20 to provide the title compound (715 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 20

Sources & evidence

ORD record
ord-a51468d0e7474d3aba4716b94af3ac40
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

Loading…