HRID1433842

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77942

N-(2-chloroethyl)-N-(propan-2-yl)propan-2-amine hydrochloride

C8H19Cl2N

结构：COc1ccc(-c2ccc3cc(OC)ccc3c2)c(C(=O)c2ccc(O)cc2)c1

HCID57933864

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccc3cc(OC)ccc3c2)c(C(=O)c2ccc(OCCN(C(C)C)C(C)C)cc2)c1

HCID23087211

未命名化合物

收率 92.5%

PROCEDURE

实验过程

Synthesized from (4-hydroxyphenyl)[5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone (1.3 g) and (2-chloroethyl)diisopropylamine hydrochloride (787 mg) according to an analogous synthetic method to Preparation Example 40, the title compound (1.6 g) was obtained.

WORKUP

后处理

customaccording to an analogous synthetic method to Preparation Example 40

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-00261d96ceea49589a54c2d60b2c6456
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612114B2
来源说明: uspto-grants-2009_11

反应 SMILES

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=2[C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=3)[CH:19]=2)=[O:9])=[CH:4][CH:3]=1.Cl.Cl[CH2:32][CH2:33][N:34]([CH:38]([CH3:40])[CH3:39])[CH:35]([CH3:37])[CH3:36]>>[CH:35]([N:34]([CH:38]([CH3:40])[CH3:39])[CH2:33][CH2:32][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=2[C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=3)[CH:19]=2)=[O:9])=[CH:6][CH:7]=1)([CH3:37])[CH3:36]