HCID 23087239, compound → HCID 66626225, compound

HRID 1433844Notes

Reaction equation

HRID 1433844 reaction equation
FC(F)(F)S(O[C:7]1[CH2:13][CH2:12][CH2:11][C:10]2[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:9]=2[CH:8]=1)(=O)=O.COC1C=CC2C=C([Sn](C)(C)C)CCCC=2C=1.[CH2:39]([O:46][C:47]1[CH:61]=[CH:60][C:50]([CH2:51][N:52]2[C:57](Br)=[CH:56][CH:55]=[CH:54][C:53]2=[O:59])=[CH:49][CH:48]=1)[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>>[CH2:39]([O:46][C:47]1[CH:61]=[CH:60][C:50]([CH2:51][N:52]2[C:57]([C:7]3[CH2:13][CH2:12][CH2:11][C:10]4[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:9]=4[CH:8]=3)=[CH:56][CH:55]=[CH:54][C:53]2=[O:59])=[CH:49][CH:48]=1)[C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1

Participants

4

Reactant 3

HCID 23087239HCID 23087239, compoundHCID 66627018HCID 66627018, compoundHCID 866052382-methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl trifluoromethanesulfonate

Product 1

HCID 66626225HCID 66626225, compound

Procedure

Synthesized from 2-methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl trifluoromethanesulfonate according to an analogous synthetic method to Preparation Example 69, (2-methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl)trimethyltin (3.25 g) and 1-(4-benzyloxybenzyl)-6-bromo-1H-pyridin-2-one (2.2 g) were used according to an analogous synthetic method to Example 1 to provide 1-(4-benzyloxybenzyl)-6-(2-methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl)-1H-pyridin-2-one (646 mg). The total amount of this compound was used according to an analogous synthetic method to Example 22 described below to provide the title compound (404 mg).

Sources & evidence

ORD record
ord-b641503971014f359baaaee6f4396202
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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