5-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine → HCID 57934450, compound

HRID 1433873Notes

Reaction equation

HRID 1433873 reaction equation
COC1C=CC(C2CCC3C(=CC=C(OC)C=3)C2)=C(N)C=1.C[O:23][C:24]1[CH:25]=[CH:26][C:27]([CH:33]2[CH2:42][CH2:41][C:40]3[C:35](=[CH:36][CH:37]=[C:38]([O:43]C)[CH:39]=3)[CH2:34]2)=[C:28]([N:30]([CH3:32])[CH3:31])[CH:29]=1>>[CH3:31][N:30]([CH3:32])[C:28]1[CH:29]=[C:24]([OH:23])[CH:25]=[CH:26][C:27]=1[CH:33]1[CH2:42][CH2:41][C:40]2[CH:39]=[C:38]([OH:43])[CH:37]=[CH:36][C:35]=2[CH2:34]1

Participants

3

Reactant 2

HCID 230872055-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamineHCID 23087376HCID 23087376, compound

Product 1

HCID 57934450HCID 57934450, compoundYield 87.9%

Procedure

Synthesized from 5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine according to an analogous synthetic method to Preparation Example 18, [5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]dimethylamine (120 mg) was used according to an analogous synthetic method to Example 364 described below to provide the title compound (96 mg).

Sources & evidence

ORD record
ord-01bddcb0f5be423d999e3cb3734e5b96
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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