6-(2-Amino-4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ol → {2-[2-(tert-Butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenyl}ethylamine

HRID 1433896Notes

Reaction equation

HRID 1433896 reaction equation
[NH2:1][C:2]1C=C(OC)C=C[C:3]=1C1CCCC2C=C(O)C=CC=2C1.[Si:22]([O:29][C:30]1[CH:31]=[CH:32][C:33]2[CH2:39][CH:38]([C:40]3[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[CH:42][C:41]=3N)[CH2:37][CH2:36][CH2:35][C:34]=2[CH:49]=1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]>>[Si:22]([O:29][C:30]1[CH:31]=[CH:32][C:33]2[CH2:39][CH:38]([C:40]3[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[CH:42][C:41]=3[CH2:3][CH2:2][NH2:1])[CH2:37][CH2:36][CH2:35][C:34]=2[CH:49]=1)([C:25]([CH3:28])([CH3:26])[CH3:27])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 579345186-(2-Amino-4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-olHCID 66627107HCID 66627107, compound

Product 1

HCID 66626847{2-[2-(tert-Butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenyl}ethylamine

Procedure

Synthesized from 6-(2-amino-4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ol according to an analogous synthetic method to Example 201 described below, 2-[2-(tert-butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenylamine (1.3 g) was used according to an analogous synthetic method to Example 36 to provide the title compound (1.1 g).

Sources & evidence

ORD record
ord-0c470216fe9041cdb289aa706c376545
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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