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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1433900Generated: October 25, 2026

4-Bromo-3-nitroanisole → 5-Methoxy-2-(6-methoxy-3,3-dimethyl-3,4-dihydronaphthalen-2-yl)phenylamine

https://huagongshe.com/reaction/1433900

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-3-nitroanisoleHCID 79288—
Reactant7-Methoxy-3-(4-methoxy-2-nitrophenyl)-2,2-dimethyl-1,2-dihydronaphthaleneHCID 23087432—
Reactant3-Bromo-7-methoxy-2,2-dimethyl-1,2-dihydronaphthaleneHCID 23087570—
Product5-Methoxy-2-(6-methoxy-3,3-dimethyl-3,4-dihydronaphthalen-2-yl)phenylamineHCID 2308732075.1%

Reaction Steps

Synthesized from 3-bromo-7-methoxy-2,2-dimethyl-1,2-dihydronaphthalene and 4-bromo-3-nitroanisole according to an analogous synthetic method to Preparation Example 107 described below, 7-methoxy-3-(4-methoxy-2-nitrophenyl)-2,2-dimethyl-1,2-dihydronaphthalene (1.9 g) was used according to an analogous synthetic method to Example 57 to provide the title compound (1.3 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-6d08f2ae0b8740c9a36a78c636795312
Source noteuspto-grants-2009_11