4-Bromo-3-nitroanisole → HCID 23087364, compound

HRID 1433904Notes

Reaction equation

HRID 1433904 reaction equation
BrC1C(C)(C)OC2C(C=1)=CC=C(OC)C=2.BrC1C=CC(OC)=CC=1[N+]([O-])=O.[CH3:28][O:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[C:35]([C:42]3[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[CH:44][C:43]=3[N+:50]([O-])=O)[C:36]([CH3:41])([CH3:40])[O:37]2)=[CH:32][CH:31]=1>>[CH3:49][O:48][C:45]1[CH:46]=[CH:47][C:42]([CH:35]2[CH2:34][C:33]3[C:38](=[CH:39][C:30]([O:29][CH3:28])=[CH:31][CH:32]=3)[O:37][C:36]2([CH3:41])[CH3:40])=[C:43]([NH2:50])[CH:44]=1

Participants

4

Reactant 3

HCID 792884-Bromo-3-nitroanisoleHCID 14970557HCID 14970557, compoundHCID 23087368HCID 23087368, compound

Product 1

HCID 23087364HCID 23087364, compoundYield 89.7%

Procedure

Synthesized from 3-bromo-7-methoxy-2,2-dimethyl-2H-chromene and 4-bromo-3-nitroanisole according to an analogous synthetic method to Preparation Example 107 described below, 7-methoxy-3-(4-methoxy-2-nitrophenyl)-2,2-dimethyl-2H-chromene (1.2 g) was used according to an analogous synthetic method to Example 30 to provide the title compound (988 mg).

Sources & evidence

ORD record
ord-bcd61806ca54436682c169ac0bf4d023
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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