HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 4-bromo-1,2-dimethoxy- → 7-Benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 4-bromo-1,2-dimethoxy- | HCID 76114 | — |
| Reactant | 4-Bromo-5-nitroveratrole | HCID 170968 | — |
| Reactant | 3-Bromo-1,2-dihydro-7-(phenylmethoxy)naphthalene | HCID 23087420 | — |
| Product | 7-Benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene | HCID 23087426 | 21.8% |
Reaction Steps
Synthesized from 1-bromo-3,4-dimethoxybenzene according to an analogous synthetic method to Preparation Example 108, 1-bromo-4,5-dimethoxy-2-nitrobenzene (7.5 g) and 7-benzyloxy-3-bromo-1,2-dihydronaphthalene (4.5 g) were used according to an analogous synthetic method to Preparation Example 107 to provide 7-benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene (1.3 g). The total amount of this compound was used according to an analogous synthetic method to Example 30 to provide the title compound (822 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-c1bd0f8be5354add8b27466babec199f |
| Source note | uspto-grants-2009_11 |