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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1433933Generated: October 26, 2026

Benzene, 4-bromo-1,2-dimethoxy- → 7-Benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene

https://huagongshe.com/reaction/1433933

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 4-bromo-1,2-dimethoxy-HCID 76114—
Reactant4-Bromo-5-nitroveratroleHCID 170968—
Reactant3-Bromo-1,2-dihydro-7-(phenylmethoxy)naphthaleneHCID 23087420—
Product7-Benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthaleneHCID 2308742621.8%

Reaction Steps

Synthesized from 1-bromo-3,4-dimethoxybenzene according to an analogous synthetic method to Preparation Example 108, 1-bromo-4,5-dimethoxy-2-nitrobenzene (7.5 g) and 7-benzyloxy-3-bromo-1,2-dihydronaphthalene (4.5 g) were used according to an analogous synthetic method to Preparation Example 107 to provide 7-benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene (1.3 g). The total amount of this compound was used according to an analogous synthetic method to Example 30 to provide the title compound (822 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-c1bd0f8be5354add8b27466babec199f
Source noteuspto-grants-2009_11