HCID 57934390, compound → HCID 57933798, compound

HRID 1433944Notes

Reaction equation

FC1C=C(C=CC=1OCCN1CCCCC1)CNC1C=C(OC)C=CC=1C1C=CC2C(=CC=C(OC)C=2)C=1.[CH2:39]([N:41]([CH2:62][C:63]1[CH:68]=[CH:67][C:66]([O:69][CH2:70][CH2:71][N:72]2[CH2:77][CH2:76][CH2:75][CH2:74][CH2:73]2)=[C:65]([F:78])[CH:64]=1)[C:42]1[CH:47]=[C:46]([O:48]C)[CH:45]=[CH:44][C:43]=1[C:50]1[CH:59]=[CH:58][C:57]2[C:52](=[CH:53][CH:54]=[C:55]([O:60]C)[CH:56]=2)[CH:51]=1)[CH3:40]>>[CH2:39]([N:41]([CH2:62][C:63]1[CH:68]=[CH:67][C:66]([O:69][CH2:70][CH2:71][N:72]2[CH2:77][CH2:76][CH2:75][CH2:74][CH2:73]2)=[C:65]([F:78])[CH:64]=1)[C:42]1[CH:47]=[C:46]([OH:48])[CH:45]=[CH:44][C:43]=1[C:50]1[CH:51]=[C:52]2[C:57](=[CH:58][CH:59]=1)[CH:56]=[C:55]([OH:60])[CH:54]=[CH:53]2)[CH3:40]

Participants

Reactant 2

HCID 57934390HCID 57934390, compound

HCID 66626966HCID 66626966, compound

Product 1

HCID 57933798HCID 57933798, compoundYield 80.6%

Procedure

Synthesized from [3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl][5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]amine according to an analogous synthetic method to Example 36, ethyl[3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl][5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]amine (297 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (227 mg).

Sources & evidence

ORD record: ord-a1e54d4443474ccbaff1aded9ca59f21
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07612114B2

Reaction notes

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