HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-(4-Bromo-2-fluorophenoxy)ethyl)piperidine → 6-{3-[3-Fluoro-4-(2-piperidin-1-ylethoxy)phenylamino]pyridin-4-yl}naphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-(4-Bromo-2-fluorophenoxy)ethyl)piperidine | HCID 23087072 | — |
| Reactant | 4-(6-Methoxynaphthalen-2-yl)pyridin-3-ylamine | HCID 23087162 | — |
| Reactant | [3-Fluoro-4-(2-piperidin-1-ylethoxy)phenyl][4-(6-methoxynaphthalen-2-yl)pyridin-3-yl]amine | HCID 23087403 | — |
| Product | 6-{3-[3-Fluoro-4-(2-piperidin-1-ylethoxy)phenylamino]pyridin-4-yl}naphthalen-2-ol | HCID 136175576 | 74.5% |
Reaction Steps
Synthesized from 4-(6-methoxynaphthalen-2-yl)pyridin-3-ylamine and 1-[2-(4-bromo-2-fluorophenoxy)ethyl]piperidine according to an analogous synthetic method to Example 116, [3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl][4-(6-methoxynaphthalen-2-yl)pyridin-3-yl]amine (343 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (248 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-54db171b55b144d797407dd4074bc05a |
| Source note | uspto-grants-2009_11 |