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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1433955Generated: November 1, 2026

1-[2-(4-Bromophenoxy)ethyl]piperidine → [5-Methoxy-2-(6-methoxy-3,4-dihydronaphthalen-2-yl)phenyl][4-(2-piperidin-1-ylethoxy)phenyl]amine

https://huagongshe.com/reaction/1433955

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[2-(4-Bromophenoxy)ethyl]piperidineHCID 867195—
Reactant5-Methoxy-2-(6-methoxy-3,4-dihydronaphthalen-2-yl)phenylamineHCID 23087218—
Product[5-Methoxy-2-(6-methoxy-3,4-dihydronaphthalen-2-yl)phenyl][4-(2-piperidin-1-ylethoxy)phenyl]amineHCID 5793416285.1%

Reaction Steps

Synthesized from 5-methoxy-2-(6-methoxy-3,4-dihydronaphthalen-2-yl)phenylamine (150 mg) and 1-[2-(4-bromophenoxy)ethyl]piperidine (155 mg) according to an analogous synthetic method to Example 116, the title compound (220 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-6028b2f57505439ea5915318a7c6a2d1
Source noteuspto-grants-2009_11