5-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine → HCID 57933951, compound

HRID 1433960Notes

Reaction equation

HRID 1433960 reaction equation
COC1C=CC(C2CCC3C(=CC=C(OC)C=3)C2)=C(N)C=1.BrC1C=CC(OCCN2CCCCCC2)=C(F)C=1.[N:40]1([CH2:47][CH2:48][O:49][C:50]2[CH:55]=[CH:54][C:53]([NH:56][C:57]3[CH:62]=[C:61]([O:63]C)[CH:60]=[CH:59][C:58]=3[CH:65]3[CH2:74][CH2:73][C:72]4[C:67](=[CH:68][CH:69]=[C:70]([O:75]C)[CH:71]=4)[CH2:66]3)=[CH:52][C:51]=2[F:77])[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[N:40]1([CH2:47][CH2:48][O:49][C:50]2[CH:55]=[CH:54][C:53]([NH:56][C:57]3[CH:62]=[C:61]([OH:63])[CH:60]=[CH:59][C:58]=3[CH:65]3[CH2:74][CH2:73][C:72]4[CH:71]=[C:70]([OH:75])[CH:69]=[CH:68][C:67]=4[CH2:66]3)=[CH:52][C:51]=2[F:77])[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1

Participants

4

Reactant 3

HCID 230872055-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamineHCID 57934176HCID 57934176, compoundHCID 66627539HCID 66627539, compound

Product 1

HCID 57933951HCID 57933951, compoundYield 47.8%

Procedure

Synthesized from 5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine and 1-[2-(4-bromo-2-fluorophenoxy)ethyl]azepane according to an analogous synthetic method to Example 116, [4-(2-azepan-1-ylethoxy)-3-fluorophenyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (146 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (66 mg).

Sources & evidence

ORD record
ord-168c66526367440ca238a4bf801bf0c2
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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