HRID1433968

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c(c1)CCC(c1ccc(OC)cc1NCc1ccc(OCCN(C(C)C)C(C)C)cc1)C2

HCID23087201

未命名化合物

结构：COc1ccc2c(c1)CCC(c1ccc(O)cc1NCc1ccc(OCCN(C(C)C)C(C)C)cc1)C2

HCID57933932

未命名化合物

PRODUCTS

生成物

结构：CC(C)N(CCOc1ccc(CNc2cc(O)ccc2C2CCc3cc(O)ccc3C2)cc1)C(C)C

HCID57934594

未命名化合物

收率 43.8%

PROCEDURE

实验过程

Synthesized from [4-(2-diisopropylaminoethoxy)benzyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (70 mg) according to an analogous synthetic method to Example 111, 3-[4-(2-diisopropylaminoethoxy)benzylamino]-4-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenol (25 mg) and 6-{2-[4-(2-diisopropylaminoethoxy)benzylamino]-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol (29 mg) were obtained. 3-[4-(2-Diisopropylaminoethoxy)benzylamino]-4-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenol:

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-12da18ca34bd42348594c5fe60f98602
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612114B2
来源说明: uspto-grants-2009_11

反应 SMILES

[CH:1]([N:4]([CH:36]([CH3:38])[CH3:37])[CH2:5][CH2:6][O:7][C:8]1[CH:35]=[CH:34][C:11]([CH2:12][NH:13][C:14]2[CH:19]=[C:18]([O:20]C)[CH:17]=[CH:16][C:15]=2[CH:22]2[CH2:31][CH2:30][C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:32]C)[CH:28]=3)[CH2:23]2)=[CH:10][CH:9]=1)([CH3:3])[CH3:2].C(N(C(C)C)CCOC1C=CC(CNC2C=C(O)C=CC=2C2CCC3C(=CC=C(OC)C=3)C2)=CC=1)(C)C>>[CH:36]([N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6][O:7][C:8]1[CH:35]=[CH:34][C:11]([CH2:12][NH:13][C:14]2[CH:19]=[C:18]([OH:20])[CH:17]=[CH:16][C:15]=2[CH:22]2[CH2:31][CH2:30][C:29]3[CH:28]=[C:27]([OH:32])[CH:26]=[CH:25][C:24]=3[CH2:23]2)=[CH:10][CH:9]=1)([CH3:37])[CH3:38]