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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1433992Generated: October 30, 2026

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid → 6-{2-[Ethyl(3-piperidin-4-ylbenzyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1433992

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acidHCID 45073791—
Reactant6-(2-(Ethylamino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl pivalateHCID 57934095—
Product6-{2-[Ethyl(3-piperidin-4-ylbenzyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793437625.3%

Reaction Steps

Synthesized from pivalic acid 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (80 mg) and 4-(3-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (100 mg) according to an analogous synthetic method to Example 209, the title compound (25 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-aa1b3ce53b9a49b3a984047f1f9c5999
Source noteuspto-grants-2009_11