HRID1433995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCNc1cc(OC)ccc1C1CCc2cc(OC(=O)C(C)(C)C)ccc2C1

HCID57934095

未命名化合物

结构：CC(C)(COc1ccc(C=O)cc1)NC(=O)OC(C)(C)C

HCID57934200

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2CCc3cc(OC(=O)C(C)(C)C)ccc3C2)c(NCCCc2ccc(OCC(C)(C)NC(=O)OC(C)(C)C)cc2)c1

HCID66627582

未命名化合物

收率 91.8%

PROCEDURE

实验过程

Synthesized from pivalic acid 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (58 mg) and tert-butyl [2-(4-formylphenoxy)-1,1-dimethylethyl]carbamate (222 mg) according to an analogous synthetic method to Example 212, the title compound (92 mg) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de6ed10b94674bb8acc673e6b6009c30
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612114B2
来源说明: uspto-grants-2009_11

反应 SMILES

[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[CH:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].[CH:29]([C:31]1[CH:49]=[CH:48][C:34]([O:35][CH2:36][C:37]([NH:40][C:41](=[O:47])[O:42][C:43]([CH3:46])([CH3:45])[CH3:44])([CH3:39])[CH3:38])=[CH:33][CH:32]=1)=O>>[C:43]([O:42][C:41]([NH:40][C:37]([CH3:39])([CH3:38])[CH2:36][O:35][C:34]1[CH:33]=[CH:32][C:31]([CH2:29][CH2:2][CH2:1][NH:3][C:4]2[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=2[CH:12]2[CH2:21][CH2:20][C:19]3[CH:18]=[C:17]([O:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])[CH:16]=[CH:15][C:14]=3[CH2:13]2)=[CH:49][CH:48]=1)=[O:47])([CH3:46])([CH3:44])[CH3:45]