6-(2-(Ethylamino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl pivalate → HCID 57934118, compound

HRID 1434004Notes

Reaction equation

HRID 1434004 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[CH:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].Cl.[N:30]1([CH2:36][CH2:37][O:38][C:39]2[CH:40]=[C:41]([CH:45]=[CH:46][CH:47]=2)[C:42](O)=O)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>>[CH2:1]([N:3]([CH2:42][C:41]1[CH:45]=[CH:46][CH:47]=[C:39]([O:38][CH2:37][CH2:36][N:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[CH:40]=1)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[CH:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2]

Participants

3

Reactant 2

HCID 579340956-(2-(Ethylamino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl pivalateHCID 66625743HCID 66625743, compound

Product 1

HCID 57934118HCID 57934118, compoundYield 86.5%

Procedure

Synthesized from pivalic acid 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (60 mg) and 3-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride (85 mg) according to an analogous synthetic method to Example 152, the title compound (70 mg) was obtained.

Sources & evidence

ORD record
ord-24d0137762574b398f60eda0999399a8
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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