HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde → (R)-6-{2-{[4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzyl]ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde | HCID 23087152 | — |
| Reactant | HCID 57934253 | HCID 57934253 | — |
| Product | (R)-6-{2-{[4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzyl]ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66627101 | 24.2% |
Reaction Steps
Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and 4-(2-dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde (55 mg) according to an analogous synthetic method to Example 264 described below and purified by LC-MS, the title compound (6.6 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-83546f39e0884caaa335c9361ad0821b |
| Source note | uspto-grants-2009_11 |