HCID 57934253, compound → (R)-6-{2-{[4-(2-Amino-2-methylpropoxy)-3-fluorobenzyl]ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 1434017Notes

Reaction equation

HRID 1434017 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].[F:29][C:30]1[CH:48]=[C:47]([CH:49]=O)[CH:46]=[CH:45][C:31]=1[O:32][CH2:33][C:34]([NH:37]C(=O)OC(C)(C)C)([CH3:36])[CH3:35]>>[NH2:37][C:34]([CH3:36])([CH3:35])[CH2:33][O:32][C:31]1[CH:45]=[CH:46][C:47]([CH2:49][CH2:2][CH2:1][NH:3][C:4]2[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=2[C@@H:12]2[CH2:21][CH2:20][C:19]3[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=3[CH2:13]2)=[CH:48][C:30]=1[F:29]

Participants

3

Reactant 2

HCID 57934253HCID 57934253, compoundHCID 57934591Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

Product 1

HCID 66625539(R)-6-{2-{[4-(2-Amino-2-methylpropoxy)-3-fluorobenzyl]ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olYield 73.6%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and tert-butyl [2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate (72 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (19 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-4ad93db987754583bd61df1fe346866f
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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