HCID 57934253, compound → HCID 66627066, compound

HRID 1434019Notes

Reaction equation

HRID 1434019 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].[CH:29]([C:31]1[CH:51]=[CH:50][C:34]([O:35][CH2:36][C:37]2([NH:42]C(=O)OC(C)(C)C)[CH2:41][CH2:40][CH2:39][CH2:38]2)=[CH:33][CH:32]=1)=O>>[NH2:42][C:37]1([CH2:36][O:35][C:34]2[CH:33]=[CH:32][C:31]([CH2:29][CH2:2][CH2:1][NH:3][C:4]3[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=3[C@@H:12]3[CH2:21][CH2:20][C:19]4[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=4[CH2:13]3)=[CH:51][CH:50]=2)[CH2:38][CH2:39][CH2:40][CH2:41]1

Participants

3

Reactant 2

HCID 57934253HCID 57934253, compoundHCID 57934423HCID 57934423, compound

Product 1

HCID 66627066HCID 66627066, compoundYield 61%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and tert-butyl [1-(4-formylphenoxymethyl)cyclopentyl]carbamate (74 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (16 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-b267d2f36d994fbba540c9579e4f2674
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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