HRID1434019

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCNc1cc(OC)ccc1[C@@H]1CCc2cc(OC(=O)C(C)(C)C)ccc2C1

HCID57934253

未命名化合物

结构：CC(C)(C)OC(=O)NC1(COc2ccc(C=O)cc2)CCCC1

HCID57934423

未命名化合物

PRODUCTS

生成物

结构：COc1ccc([C@@H]2CCc3cc(O)ccc3C2)c(NCCCc2ccc(OCC3(N)CCCC3)cc2)c1

HCID66627066

未命名化合物

收率 61%

PROCEDURE

实验过程

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and tert-butyl [1-(4-formylphenoxymethyl)cyclopentyl]carbamate (74 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (16 mg) was obtained.

WORKUP

后处理

custompurified by LC-MS

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b267d2f36d994fbba540c9579e4f2674
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612114B2
来源说明: uspto-grants-2009_11

反应 SMILES

[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].[CH:29]([C:31]1[CH:51]=[CH:50][C:34]([O:35][CH2:36][C:37]2([NH:42]C(=O)OC(C)(C)C)[CH2:41][CH2:40][CH2:39][CH2:38]2)=[CH:33][CH:32]=1)=O>>[NH2:42][C:37]1([CH2:36][O:35][C:34]2[CH:33]=[CH:32][C:31]([CH2:29][CH2:2][CH2:1][NH:3][C:4]3[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=3[C@@H:12]3[CH2:21][CH2:20][C:19]4[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=4[CH2:13]3)=[CH:51][CH:50]=2)[CH2:38][CH2:39][CH2:40][CH2:41]1