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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434025Generated: November 4, 2026

Pivalic acid 6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester → 6-{2-{[4-(2-Azepan-1-ylethyl)benzyl]ethylamino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1434025

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPivalic acid 6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57933854—
Reactant4-(2-Azepan-1-ylethyl)benzoic acid hydrochlorideHCID 66625504—
Product6-{2-{[4-(2-Azepan-1-ylethyl)benzyl]ethylamino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 6662786948.5%

Reaction Steps

Synthesized from pivalic acid 6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (50 mg) and 4-(2-azepan-1-ylethyl)benzoic acid hydrochloride (100 mg) according to an analogous synthetic method to Example 337 described below, the title compound (32 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-861d9ab5b7b640dca35b137bc222b136
Source noteuspto-grants-2009_11