HRID1434044

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC1(COc2ccc(C=O)cc2)CCCC1

HCID57934423

未命名化合物

结构：CCNc1cc(OC)c(OC)cc1[C@@H]1CCc2cc(OC(=O)C(C)(C)C)ccc2C1

HCID57934541

未命名化合物

PRODUCTS

生成物

结构：COc1cc(NCCCc2ccc(OCC3(N)CCCC3)cc2)c([C@@H]2CCc3cc(O)ccc3C2)cc1OC

HCID66627789

未命名化合物

收率 93.1%

PROCEDURE

实验过程

Synthesized from pivalic acid (R)-6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and tert-butyl[1-(4-formylphenoxymethyl)cyclopentyl]carbamate (74 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (24 mg) was obtained.

WORKUP

后处理

custompurified by LC-MS

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d5f446e6d71d402f810f0ded15d63e1e
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612114B2
来源说明: uspto-grants-2009_11

反应 SMILES

[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=1[C@@H:14]1[CH2:23][CH2:22][C:21]2[CH:20]=[C:19]([O:24]C(=O)C(C)(C)C)[CH:18]=[CH:17][C:16]=2[CH2:15]1)[CH3:2].C(OC(=O)[NH:37][C:38]1([CH2:43][O:44][C:45]2[CH:50]=[CH:49][C:48]([CH:51]=O)=[CH:47][CH:46]=2)[CH2:42][CH2:41][CH2:40][CH2:39]1)(C)(C)C>>[NH2:37][C:38]1([CH2:43][O:44][C:45]2[CH:50]=[CH:49][C:48]([CH2:51][CH2:2][CH2:1][NH:3][C:4]3[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=3[C@@H:14]3[CH2:23][CH2:22][C:21]4[CH:20]=[C:19]([OH:24])[CH:18]=[CH:17][C:16]=4[CH2:15]3)=[CH:47][CH:46]=2)[CH2:42][CH2:41][CH2:40][CH2:39]1