Pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester → 6-{6-[(4-Azepan-1-ylmethylbenzyl)ethylamino]benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 1434046Notes

Reaction equation

HRID 1434046 reaction equation
[CH2:1]([NH:3][C:4]1[C:5]([CH:13]2[CH2:22][CH2:21][C:20]3[CH:19]=[C:18]([O:23]C(=O)C(C)(C)C)[CH:17]=[CH:16][C:15]=3[CH2:14]2)=[CH:6][C:7]2[O:11][CH2:10][O:9][C:8]=2[CH:12]=1)[CH3:2].Cl.[N:31]1([CH2:38][C:39]2[CH:47]=[CH:46][C:42]([C:43](O)=O)=[CH:41][CH:40]=2)[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[N:31]1([CH2:38][C:39]2[CH:47]=[CH:46][C:42]([CH2:43][CH2:2][CH2:1][NH:3][C:4]3[C:5]([CH:13]4[CH2:22][CH2:21][C:20]5[CH:19]=[C:18]([OH:23])[CH:17]=[CH:16][C:15]=5[CH2:14]4)=[CH:6][C:7]4[O:11][CH2:10][O:9][C:8]=4[CH:12]=3)=[CH:41][CH:40]=2)[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 57934012Pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 66627565HCID 66627565, compound

Product 1

HCID 666267026-{6-[(4-Azepan-1-ylmethylbenzyl)ethylamino]benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-olYield 27%

Procedure

Synthesized from pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (40 mg) and 4-azepan-1-ylmethylbenzoic acid hydrochloride (80 mg) according to an analogous synthetic method to Example 337 described below, the title compound (14 mg) was obtained.

Sources & evidence

ORD record
ord-6ccab2c276f445b9b54ed42f7fb12db0
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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