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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434049Generated: October 30, 2026

4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester → 6-{6-{Ethyl[4-(1-methylpiperidin-4-yl)benzyl]amino}benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1434049

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl esterHCID 22492859—
ReactantPivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57934012—
Product6-{6-{Ethyl[4-(1-methylpiperidin-4-yl)benzyl]amino}benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793384069.4%

Reaction Steps

Synthesized from pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (40 mg) and 4-(4-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (60 mg) according to an analogous synthetic method to Example 337 described below, the title compound (35 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-a4bbc1b214934113b25d2d1bdfbe48df
Source noteuspto-grants-2009_11