HRID1434092

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID867195

1-[2-(4-bromophenoxy)ethyl]piperidine

C13H18BrNO

结构：CC(C)(C)[Si](C)(C)Oc1ccc(-c2ccc3c(c2)CCC3O[Si](C)(C)C(C)(C)C)c(N)c1

HCID57934387

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)Oc1ccc(-c2ccc3c(c2)CCC3O[Si](C)(C)C(C)(C)C)c(Nc2ccc(OCCN3CCCCC3)cc2)c1

HCID57933787

未命名化合物

收率 65.2%

PROCEDURE

实验过程

Synthesized from 5-(tert-butyldimethylsilyloxy)-2-[1-(tert-butyldimethylsilyloxy)indan-5-yl]phenylamine (635 mg) and 1-[2-(4-bromophenoxy)ethyl]piperidine (385 mg) according to an analogous synthetic method to Example 116, the title compound (593 mg) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce3e71dd336c4f128431633a21849967
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612114B2
来源说明: uspto-grants-2009_11

反应 SMILES

[Si:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[CH:21]([O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27])[CH2:20][CH2:19]3)=[C:13]([NH2:15])[CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Br[C:34]1[CH:48]=[CH:47][C:37]([O:38][CH2:39][CH2:40][N:41]2[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]2)=[CH:36][CH:35]=1>>[Si:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[CH:21]([O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:27])[CH3:28])[CH2:20][CH2:19]3)=[C:13]([NH:15][C:34]2[CH:35]=[CH:36][C:37]([O:38][CH2:39][CH2:40][N:41]3[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46]3)=[CH:47][CH:48]=2)[CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]