HCID 57933805, compound → HCID 57934364, compound

HRID 1434099Notes

Reaction equation

HRID 1434099 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:17][CH2:18][NH:19][C:20]2[CH:25]=[C:24]([O:26]C)[CH:23]=[CH:22][C:21]=2[CH:28]2[CH2:37][CH2:36][C:35]3[C:30](=[CH:31][CH:32]=[C:33]([O:38]C)[CH:34]=3)[CH2:29]2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.F[C:41]1C=C(CCNCC2C=C(OC)C=CC=2C2CCC3C(=CC=C(OC)C=3)C2)C=CC=1OCCN1CCCCC1>>[F:1][C:2]1[CH:3]=[C:4]([CH2:17][CH2:18][N:19]([CH3:41])[C:20]2[CH:25]=[C:24]([OH:26])[CH:23]=[CH:22][C:21]=2[CH:28]2[CH2:37][CH2:36][C:35]3[CH:34]=[C:33]([OH:38])[CH:32]=[CH:31][C:30]=3[CH2:29]2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 57933805HCID 57933805, compoundHCID 66627717HCID 66627717, compound

Product 1

HCID 57934364HCID 57934364, compound

Procedure

Synthesized from {2-[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]ethyl}[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine according to an analogous synthetic method to Preparation Example 18, {2-[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]ethyl}[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]methylamine (180 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (110 mg).

Sources & evidence

ORD record
ord-f741647f981c4e0a9291bb4a988e3524
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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