5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamine → {5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}[4-(2-piperidin-1-ylethoxy)benzyl]amine

HRID 1434106Notes

Reaction equation

HRID 1434106 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)=[C:7]([NH2:9])[CH:8]=1.Cl.[N:21]1([CH2:27][CH2:28][O:29][C:30]2[CH:38]=[CH:37][C:33]([C:34](Cl)=O)=[CH:32][CH:31]=2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=2)=[C:7]([NH:9][CH2:34][C:33]2[CH:32]=[CH:31][C:30]([O:29][CH2:28][CH2:27][N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:38][CH:37]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 112190855-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamineHCID 161119224-(2-Piperidin-1-ylethoxy)benzoyl chloride hydrochloride

Product 1

HCID 11340477{5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}[4-(2-piperidin-1-ylethoxy)benzyl]amineYield 73.2%

Procedure

Synthesized from 5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamine (643 mg) and 4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride (989 mg) according to an analogous synthetic method to Example 152, the title compound (868 mg) was obtained.

Sources & evidence

ORD record
ord-d6ab832037694e5ba977a574ddc5d1db
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

Loading…