HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride → 3-[3-Fluoro-4-(2-piperidin-1-ylethoxy)benzylamino]-4-[2-(4-hydroxyphenyl)vinyl]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride | HCID 23087126 | — |
| Reactant | Acetic acid 4-[2-(4-acetoxy-2-aminophenyl)vinyl]phenyl ester | HCID 66625610 | — |
| Product | 3-[3-Fluoro-4-(2-piperidin-1-ylethoxy)benzylamino]-4-[2-(4-hydroxyphenyl)vinyl]phenol | HCID 66626315 | 20% |
Reaction Steps
Synthesized from acetic acid 4-[2-(4-acetoxy-2-aminophenyl)vinyl]phenyl ester (300 mg) and 3-fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride (370 mg) according to an analogous synthetic method to Example 152, the title compound (89 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-d1f1587f7ba34cdf8de2d1b2d42aa395 |
| Source note | uspto-grants-2009_11 |