HCID 66627207, compound → HCID 66627208, compound

HRID 1434138Notes

Reaction equation

[CH2:1]([N:3]([C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[CH:30]1[CH2:39][CH2:38][C:37]2[C:32](=[CH:33][CH:34]=[C:35]([O:40][CH3:41])[CH:36]=2)[CH2:31]1)[C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13](=O)[N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)[CH3:2].[CH2:42](N(C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)CC1C=CC(OCCN2CCNCC2)=CC=1)C>>[CH2:1]([N:3]([C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[CH:30]1[CH2:39][CH2:38][C:37]2[C:32](=[CH:33][CH:34]=[C:35]([O:40][CH3:41])[CH:36]=2)[CH2:31]1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][N:17]([CH3:42])[CH2:18][CH2:19]2)=[CH:7][CH:6]=1)[CH3:2]

Participants

Reactant 2

HCID 66627207HCID 66627207, compound

HCID 66627277HCID 66627277, compound

Product 1

HCID 66627208HCID 66627208, compound

Procedure

Synthesized from N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-4-(2-oxo-2-piperazin-1-ylethoxy)benzamide according to an analogous synthetic method to Example 337, ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl][4-(2-piperazin-1-ylethoxy)benzyl]amine (650 mg) was used according to an analogous synthetic method to Preparation Example 18 to provide ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]{4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl}amine (490 mg). The total amount of this compound was used according to an analogous synthetic method to Example 111 to provide the title compound (70 mg).

Workup

customwas used according to an analogous synthetic method to Preparation Example 18

Sources & evidence

ORD record: ord-f35e0ae1eb0a43b398c6c9199b81be7e
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07612114B2

Reaction notes

Loading…