1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 57934350, compound

HRID 1434139Notes

Reaction equation

HRID 1434139 reaction equation
[CH2:1]([N:3]([C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH:21]1[CH2:30][CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[C:26]([O:31][CH3:32])[CH:27]=2)[CH2:22]1)[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH3:2].Cl.[CH2:34]([N:36]([CH2:40][CH3:41])[CH2:37][CH2:38]Cl)[CH3:35]>>[CH2:34]([N:36]([CH2:40][CH3:41])[CH2:37][CH2:38][O:11][C:8]1[CH:7]=[CH:6][C:5]([C:4]([N:3]([CH2:1][CH3:2])[C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH:21]2[CH2:30][CH2:29][C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:31][CH3:32])[CH:27]=3)[CH2:22]2)=[O:12])=[CH:10][CH:9]=1)[CH3:35]

Participants

3

Reactant 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 57934373HCID 57934373, compound

Product 1

HCID 57934350HCID 57934350, compoundYield 72.5%

Procedure

Synthesized from N-ethyl-4-hydroxy-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]benzamide (250 mg) and 2-diethylaminoethyl chloride hydrochloride (130 mg) according to an analogous synthetic method to Preparation Example 40, the title compound (223 mg) was obtained.

Workup

  1. customaccording to an analogous synthetic method to Preparation Example 40

Sources & evidence

ORD record
ord-a506648e46e741a7a273c19258aa231c
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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