HRID1434139

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13363

1-Chloro-2-(diethylamine)ethane hydrochloride

C6H15Cl2N

结构：CCN(C(=O)c1ccc(O)cc1)c1cc(OC)ccc1C1CCc2cc(OC)ccc2C1

HCID57934373

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCOc1ccc(C(=O)N(CC)c2cc(OC)ccc2C2CCc3cc(OC)ccc3C2)cc1

HCID57934350

未命名化合物

收率 72.5%

PROCEDURE

实验过程

Synthesized from N-ethyl-4-hydroxy-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]benzamide (250 mg) and 2-diethylaminoethyl chloride hydrochloride (130 mg) according to an analogous synthetic method to Preparation Example 40, the title compound (223 mg) was obtained.

WORKUP

后处理

customaccording to an analogous synthetic method to Preparation Example 40

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a506648e46e741a7a273c19258aa231c
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07612114B2
来源说明: uspto-grants-2009_11

反应 SMILES

[CH2:1]([N:3]([C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH:21]1[CH2:30][CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[C:26]([O:31][CH3:32])[CH:27]=2)[CH2:22]1)[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH3:2].Cl.[CH2:34]([N:36]([CH2:40][CH3:41])[CH2:37][CH2:38]Cl)[CH3:35]>>[CH2:34]([N:36]([CH2:40][CH3:41])[CH2:37][CH2:38][O:11][C:8]1[CH:7]=[CH:6][C:5]([C:4]([N:3]([CH2:1][CH3:2])[C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH:21]2[CH2:30][CH2:29][C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:31][CH3:32])[CH:27]=3)[CH2:22]2)=[O:12])=[CH:10][CH:9]=1)[CH3:35]