1-(Azetidin-1-yl)-2-chloroethan-1-one → 6-{2-{[4-(2-Azetidin-1-ylethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

Participants

Role	Name	HCID	Charge
Reactant	1-(Azetidin-1-yl)-2-chloroethan-1-one	HCID 2543159	—
Reactant	Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester	HCID 57934527	—
Product	6-{2-{[4-(2-Azetidin-1-ylethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol	HCID 57934002	45.3%

Reaction Steps

Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 1-azetidin-1-yl-2-chloroethanone (13 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (11 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612114B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-b777e899353d47908c0ab829127717bc
Source note	uspto-grants-2009_11