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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434177Generated: October 26, 2026

1-(Chloroacetyl)azocane → 6-{2-{[4-(2-Azocan-1-ylethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1434177

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Chloroacetyl)azocaneHCID 16226899—
ReactantPivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57934527—
Product6-{2-{[4-(2-Azocan-1-ylethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793443735.3%

Reaction Steps

Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 1-azocan-1-yl-2-chloroethanone (18 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (9.5 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-ad435620a13443df810f77cc77fca167
Source noteuspto-grants-2009_11