Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester → 6-{2-{{3-Fluoro-4-[2-(4-methyl-[1,4]diazepan-1-yl)ethoxy]benzyl}isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

Participants

Role	Name	HCID	Charge
Reactant	Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester	HCID 57934527	—
Reactant	Tert-butyl 4-(2-chloroacetyl)-1,4-diazepane-1-carboxylate	HCID 57934585	—
Product	6-{2-{{3-Fluoro-4-[2-(4-methyl-[1,4]diazepan-1-yl)ethoxy]benzyl}isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol	HCID 57933940	59.3%

Reaction Steps

Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 4-(2-chloroacetyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (26 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (16 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07612114B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-2b9a8ccc37374cc289e216711421d57c
Source note	uspto-grants-2009_11