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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434188Generated: October 25, 2026

1-(Chloroacetyl)pyrrolidine → 6-{2-{Isopropyl[4-(2-pyrrolidin-1-ylethoxy)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1434188

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Chloroacetyl)pyrrolidineHCID 88440—
ReactantPivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57933955—
Product6-{2-{Isopropyl[4-(2-pyrrolidin-1-ylethoxy)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793381580.1%

Reaction Steps

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (30 mg) and 2-chloro-1-pyrrolidin-1-ylethanone (17 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (24 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-0e44197e3c49474484e95d584f1da7af
Source noteuspto-grants-2009_11