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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434208Generated: November 1, 2026

2-Bromo-1-(2,2,6,6-tetramethylpiperidin-1-yl)ethanone → 6-{2-{Ethyl {4-[2-(2,2,6,6-tetramethylpiperidin-1-yl)ethoxy]benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1434208

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-(2,2,6,6-tetramethylpiperidin-1-yl)ethanoneHCID 23087449—
ReactantPivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57934562—
Product6-{2-{Ethyl {4-[2-(2,2,6,6-tetramethylpiperidin-1-yl)ethoxy]benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793395430.2%

Reaction Steps

Synthesized from pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 2-bromo-1-(2,2,6,6-tetramethylpiperidin-1-yl)ethanone (26 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (8.6 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-a7bfc8c3dd72434c87ef6a4761ce3c36
Source noteuspto-grants-2009_11