HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Azetidin-1-yl)-2-chloroethan-1-one → 6-{2-{[4-(2-Azetidin-1-ylethoxy)benzyl]methylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Azetidin-1-yl)-2-chloroethan-1-one | HCID 2543159 | — |
| Reactant | Pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 66626427 | — |
| Product | 6-{2-{[4-(2-Azetidin-1-ylethoxy)benzyl]methylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66627266 | 19.8% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 1-azetidin-1-yl-2-chloroethanone (14 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (4.8 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4ade2d6839e64c4cbc518419a7ba7030 |
| Source note | uspto-grants-2009_11 |