HCID 45081166, compound → HCID 66627736, compound

HRID 1434236Notes

Reaction equation

HRID 1434236 reaction equation
[OH:1][C:2]1[CH:36]=[CH:35][C:5]([C:6]([CH2:8][NH:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=2[CH:18]2[CH2:27][CH2:26][C:25]3[CH:24]=[C:23]([O:28]C(=O)C(C)(C)C)[CH:22]=[CH:21][C:20]=3[CH2:19]2)=O)=[CH:4][CH:3]=1.[CH:37]12[N:43]([C:44](=O)[CH2:45]Br)[CH:40]([CH2:41][CH2:42]1)[CH2:39][CH2:38]2>>[CH:37]12[N:43]([CH2:44][CH2:45][O:1][C:2]3[CH:36]=[CH:35][C:5]([CH2:6][CH2:8][NH:9][C:10]4[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=4[CH:18]4[CH2:27][CH2:26][C:25]5[CH:24]=[C:23]([OH:28])[CH:22]=[CH:21][C:20]=5[CH2:19]4)=[CH:4][CH:3]=3)[CH:40]([CH2:41][CH2:42]1)[CH2:39][CH2:38]2

Participants

3

Reactant 2

HCID 45081166HCID 45081166, compoundHCID 66626427Pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 66627736HCID 66627736, compoundYield 57.1%

Procedure

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone (22 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (15 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-905e255c5ade44a0b2673a0be38673d7
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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