2-Bromo-1-(2,2,6,6-tetramethylpiperidin-1-yl)ethanone → 6-{2-{{3-Fluoro-4-[2-(2,2,6,6-tetramethylpiperidin-1-yl)ethoxy]benzyl}methylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

Participants

Reaction Steps

Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and 2-bromo-1-(2,2,6,6-tetramethylpiperidin-1-yl)ethanone (21 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (7.7 mg) was obtained.

Provenance & Evidence