HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloroethyl)azepane → 6-{2-{[4-(2-Azepan-1-yl-ethoxy)benzyl]propylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloroethyl)azepane | HCID 16625 | — |
| Reactant | Pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 66626482 | — |
| Product | 6-{2-{[4-(2-Azepan-1-yl-ethoxy)benzyl]propylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66626322 | 28.5% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (30 mg) and 1-(2-chloroethyl)azepane (23 mg) according to an analogous synthetic method to Example 404 and purified by NH silica gel column chromatography (hexane-ethyl acetate system), the title compound (9 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-e76060c5a45b4537bf2e3f2e0d2b2e69 |
| Source note | uspto-grants-2009_11 |