HCID 45081166, compound → HCID 66626825, compound

HRID 1434277Notes

Reaction equation

HRID 1434277 reaction equation
C([N:3]([C:31](=O)[C:32]1[CH:37]=[CH:36][C:35](O)=[CH:34]C=1)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=1[CH:14]1[CH2:23][CH2:22][C:21]2[CH:20]=[C:19]([O:24]C(=O)C(C)(C)C)[CH:18]=[CH:17][C:16]=2[CH2:15]1)C.[CH:40]12[N:46]([C:47](=O)[CH2:48]Br)[CH:43]([CH2:44][CH2:45]1)[CH2:42][CH2:41]2>>[CH:40]12[N:46]([CH2:47][CH2:48][O:10][C:8]3[CH:7]=[CH:6][C:36]([CH2:37][CH2:32][CH2:31][NH:3][C:4]4[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=4[CH:14]4[CH2:23][CH2:22][C:21]5[CH:20]=[C:19]([OH:24])[CH:18]=[CH:17][C:16]=5[CH2:15]4)=[CH:35][CH:34]=3)[CH:43]([CH2:44][CH2:45]1)[CH2:42][CH2:41]2

Participants

3

Reactant 2

HCID 45081166HCID 45081166, compoundHCID 66626109Pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 66626825HCID 66626825, compoundYield 17.1%

Procedure

Synthesized from pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone (15 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (1.7 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-acc59696bec640ffb04de1e4db38823b
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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