HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-(2-methoxyethyl)-N-methylacetamide → (R)-6-{2-{Ethyl{3-fluoro-4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-(2-methoxyethyl)-N-methylacetamide | HCID 15174913 | — |
| Reactant | pivalic acid (R)-6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57933882 | — |
| Product | (R)-6-{2-{Ethyl{3-fluoro-4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934566 | 23.7% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and 2-chloro-N-(2-methoxyethyl)-N-methylacetamide (13 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (4.9 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-b025431b0dc94f30b1ad73ea99f21e44 |
| Source note | uspto-grants-2009_11 |