HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Chloroacetyl)pyrrolidine → (R)-6-{2-{Ethyl[4-(2-pyrrolidin-1-ylethoxy)benzyl]amino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Chloroacetyl)pyrrolidine | HCID 88440 | — |
| Reactant | Pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934042 | — |
| Product | (R)-6-{2-{Ethyl[4-(2-pyrrolidin-1-ylethoxy)benzyl]amino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 58023117 | 48.8% |
Reaction Steps
Synthesized from pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (16 mg) and 2-chloro-1-pyrrolidin-1-ylethanone (8.0 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (7.8 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612114B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-58002ab009674ad79f8394879c64f10c |
| Source note | uspto-grants-2009_11 |