1-(Chloroacetyl)pyrrolidine → HCID 57934360, compound

HRID 1434381Notes

Reaction equation

HRID 1434381 reaction equation
[CH2:1]([N:3]([C:27](=O)[C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C@@H:10]1[CH2:19][CH2:18][C:17]2[CH:16]=[C:15]([O:20]C(=O)C(C)(C)C)[CH:14]=[CH:13][C:12]=2[CH2:11]1)[CH3:2].Cl[CH2:37][C:38]([N:40]1[CH2:44][CH2:43][CH2:42][CH2:41]1)=O>>[CH2:1]([N:3]([CH2:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH2:37][CH2:38][N:40]2[CH2:44][CH2:43][CH2:42][CH2:41]2)=[CH:30][CH:29]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C@@H:10]1[CH2:19][CH2:18][C:17]2[CH:16]=[C:15]([OH:20])[CH:14]=[CH:13][C:12]=2[CH2:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 884401-(Chloroacetyl)pyrrolidineHCID 57934191HCID 57934191, compound

Product 1

HCID 57934360HCID 57934360, compoundYield 47.3%

Procedure

Synthesized from pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (18 mg) and 2-chloro-1-pyrrolidin-1-ylethanone (11 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (8.5 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-80a6a9de4536499fb861b8b1ec015acb
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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