N-Methylbutylamine → HCID 66627029, compound

HRID 1434390Notes

Reaction equation

HRID 1434390 reaction equation
[C:1]([CH2:4][C:5]1[CH:39]=[CH:38][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[C@@H:21]2[CH2:30][CH2:29][C:28]3[CH:27]=[C:26]([O:31]C(=O)C(C)(C)C)[CH:25]=[CH:24][C:23]=3[CH2:22]2)=[CH:7][CH:6]=1)(O)=O.[CH2:40]([NH:44][CH3:45])[CH2:41][CH2:42][CH3:43]>>[CH2:40]([N:44]([CH3:45])[CH2:1][CH2:4][C:5]1[CH:39]=[CH:38][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[C@@H:21]2[CH2:30][CH2:29][C:28]3[CH:27]=[C:26]([OH:31])[CH:25]=[CH:24][C:23]=3[CH2:22]2)=[CH:7][CH:6]=1)[CH2:41][CH2:42][CH3:43]

Participants

3

Reactant 2

HCID 8068N-MethylbutylamineHCID 86605261HCID 86605261, compound

Product 1

HCID 66627029HCID 66627029, compoundYield 17.8%

Procedure

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and butylmethylamine (22 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (3.2 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-b25016113fe54f9c9105b50dfe266da5
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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