HCID 11417530, compound → HCID 57934019, compound

HRID 1434417Notes

Reaction equation

HRID 1434417 reaction equation
COC1C=C(OC2C=CC(O)=CC=2)C2CC(C3C=CC(OC)=CC=3)CCC=2C=1.Cl.ClCCN1CCCCCC1.C[O:41][C:42]1[CH:43]=[C:44]([O:60][C:61]2[CH:76]=[CH:75][C:64]([O:65][CH2:66][CH2:67][N:68]3[CH2:74][CH2:73][CH2:72][CH2:71][CH2:70][CH2:69]3)=[CH:63][CH:62]=2)[C:45]2[CH2:46][CH:47]([C:52]3[CH:57]=[CH:56][C:55]([O:58]C)=[CH:54][CH:53]=3)[CH2:48][CH2:49][C:50]=2[CH:51]=1>>[N:68]1([CH2:67][CH2:66][O:65][C:64]2[CH:63]=[CH:62][C:61]([O:60][C:44]3[C:45]4[CH2:46][CH:47]([C:52]5[CH:57]=[CH:56][C:55]([OH:58])=[CH:54][CH:53]=5)[CH2:48][CH2:49][C:50]=4[CH:51]=[C:42]([OH:41])[CH:43]=3)=[CH:76][CH:75]=2)[CH2:74][CH2:73][CH2:72][CH2:71][CH2:70][CH2:69]1

Participants

4

Reactant 3

HCID 11417530HCID 11417530, compoundHCID 24188283N-(2-chloroethyl)perhydroazepine hydrochlorideHCID 66627807HCID 66627807, compound

Product 1

HCID 57934019HCID 57934019, compoundYield 35.6%

Procedure

Synthesized from 4-[3-methoxy-7-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-1-yloxy]phenol and 1-(2-chloroethyl)azepane hydrochloride according to an analogous synthetic method to Preparation Example 40, 1-{2-{4-[3-methoxy-7-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-1-yloxy]phenoxy}ethyl}azepane (345 mg) was used according to an analogous synthetic method to Example 779 described below to provide the title compound (116 mg).

Sources & evidence

ORD record
ord-aaf26b8392d0463d861cf1a4e17aa8c7
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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