Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 66627730, compound

HRID 1434419Notes

Reaction equation

HRID 1434419 reaction equation
C[O:2]C1C=C(OC2C=CC(O)=CC=2)C2CC(C3C=CC(OC)=CC=3)CCC=2C=1.Cl.ClCCN1CCCCC1.CO[C:41]1[CH:42]=[C:43]([O:59][C:60]2[CH:74]=[CH:73][C:63]([O:64][CH2:65][CH2:66][N:67]3[CH2:72][CH2:71][CH2:70][CH2:69][CH2:68]3)=[CH:62][CH:61]=2)[C:44]2[CH2:45][CH:46]([C:51]3[CH:56]=[CH:55][C:54]([O:57]C)=[CH:53][CH:52]=3)[CH2:47][CH2:48][C:49]=2[CH:50]=1>>[OH:57][C:54]1[CH:53]=[CH:52][C:51]([CH:46]2[CH2:47][CH2:48][C:49]3[C:50]([OH:2])=[CH:41][CH:42]=[C:43]([O:59][C:60]4[CH:61]=[CH:62][C:63]([O:64][CH2:65][CH2:66][N:67]5[CH2:72][CH2:71][CH2:70][CH2:69][CH2:68]5)=[CH:73][CH:74]=4)[C:44]=3[CH2:45]2)=[CH:56][CH:55]=1

Participants

4

Reactant 3

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 11417530HCID 11417530, compoundHCID 66627540HCID 66627540, compound

Product 1

HCID 66627730HCID 66627730, compound

Procedure

Synthesized from 4-[3-methoxy-7-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-1-yloxy]phenol and 1-(2-chloroethyl)piperidine hydrochloride according to an analogous synthetic method to Preparation Example 40, 1-{2-{4-[3-methoxy-7-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-1-yloxy]phenoxy}ethyl}piperidine (180 mg) was used according to an analogous synthetic method to Example 779 described below to provide the title compound (104 mg).

Sources & evidence

ORD record
ord-10a564a44d704b02994f5da28a78e261
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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